JCOGP
Journal of Controversies in Obstetrics & Gynecology and Pediatrics

As of January 2023, our "Journal of Controversies Obstetrics & Gynecology and Pediatrics" has been published under the Medihealth Academy to publish all articles, reviews and case reports on Pediatrics, especially in the field of Obstetrics and Gynecology. In order to facilitate the citation of the articles, to take our place in internationally respected indexes and to reach a wider readership, we will pay attention to the fact that our article language is only English in terms of acceptance. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

eISSN: 2980-0579
Creative Commons CC BY-NC-ND 4.0 International License.
EndNote Style

Online Manuscript System

Index
Original Article
Is vitamin D level important in pregnant women with COVID-19?
Abstract
Aims: The Covid-19 pandemic started in Wuhan City, Hubei Province, China in late December 2019. In our study, we aimed to evaluate the effectiveness of vitamin D levels on the clinic of the disease, laboratory findings, severity of the disease and, length of hospital stay by grouping pregnant patients with a diagnosis of Covid-19 according to their vitamin D levels.
Methods: A total of 125 patients were included. According to the vitamin D levels of the patients at the time of hospitalization, two groups were determined as below and above 20ng/ml, which is the limit of vitamin D deficiency. The patients in these two groups were compared in terms of demographic features, clinical findings, laboratory findings, imaging findings, hospitalization times and need for intensive care.
Results: When evaluated according to serum 25 hydroxyvitamin D level, patients’ fever, pulse, oxygen saturation, the severity of lung involvement in computed tomography, hospitalization there was no statistically significant difference between the groups in terms of duration and need for intensive care. When the laboratory parameters of the patients at hospitalization were compared according to serum 25 hydroxyvitamin D levels, there was no statistically significant difference between the two groups in terms of any laboratory parameter. As a result of the analysis, only lymphocyte count was determined as the independent variable affecting the severity of lung involvement in thorax CT (Computed tomography). As the lymphocyte count decreased, the severity of involvement in thorax CT increased.
Conclusion: Our study showed that vitamin D level did not have a significant relationship with any of the parameters related to Covid-19 such as clinical and laboratory findings, severity of the disease and duration of hospitalisation. It is also supported by our study that the decrease in lymphocyte counts is associated with severe Covid-19 disease.

Keywords : Vitamin D, pregnancy, COVID-19

Download Article


1. Zhou F, Yu T, Du R, et al. Clinical course and risk factors formortality of adult inpatients with COVID-19 in Wuhan, China: aretrospective cohort study [published correction appears in. Lancet.2020;395(10229):1038.
2. WHO (World Health Organization) Coronavirus disease(COVID-2019) situation reports.2020.https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports.
3. Muralidar S, Ambi SV, Sekaran S, Krishnan UM. The emergence ofCOVID-19 as a global pandemic: Understanding the epidemiology,immune response and potential therapeutic targets of SARS-CoV-2.Biochimie. 2020;179:85-100.
4. Wu Z, McGoogan JM. Characteristics of and important lessons fromthe Coronavirus disease (COVID-19) outbreak in China: summary ofa report of 72 314 cases from the chinese center for disease control andprevention.JAMA. 2020;323(13):1239-1242.
5. Ejaz H, Alsrhani A, Zafar A, et al. COVID-19 and comorbidities:Deleterious impact on infected patients.J Infect Public Health.2020;13(12):1833-1839.
6. Zambrano LD, Ellington S, Strid P, et al. Update: characteristics ofsymptomatic women of reproductive age with laboratory-confirmedsars-cov-2 infection by pregnancy status - united states. MMWR MorbMortal Wkly Rep. 2020;69(44):1641-1647.
7. Rasmussen SA, Jamieson DJ. COVID-19 and Pregnancy.Infect Dis ClinNorth Am. 2022;36(2):423-433.
8. Bouillon R, Carmeliet G, Verlinden L, et al. Vitamin D and humanhealth: lessons from vitamin D receptor null mice.Endocr Rev.2008;29(6):726-776.
9. Müller K, Diamant M, Bendtzen K. Inhibition of production andfunction of interleukin-6 by 1,25-dihydroxyvitamin D3.Immunol Lett.1991;28(2):115-120.
10. Jakovac H. COVID-19 and vitamin D-Is there a link and an opportunityfor intervention?.Am J Physiol Endocrinol Metab. 2020;318(5):589.
11. Liu PT, Stenger S, Li H, et al. Toll-like receptor triggering of avitamin D-mediated human antimicrobial response.Science.2006;311(5768):1770-1773.
12. Tripathi S, Tecle T, Verma A, Crouch E, White M, Hartshorn KL.The human cathelicidin LL-37 inhibits influenza A viruses through amechanism distinct from that of surfactant protein D or defensins.JGen Virol. 2013;94(1):40-49.
13. Chen J, Mei K, Xie L, et al. Low vitamin D levels do not aggravateCOVID-19 risk or death, and vitamin D supplementation does notimprove outcomes in hospitalized patients with COVID-19: a meta-analysis and GRADE assessment of cohort studies and RCTs.Nutr J.2021;20(1):89.
14. Hastie CE, Pell JP, Sattar N. Vitamin D and COVID-19 infection andmortality in UK Biobank.Eur J Nutr. 2021;60(1):545-548.
15. Chen N, Zhou M, Dong X, et al. Epidemiological and clinicalcharacteristics of 99 cases of 2019 novel coronavirus pneumonia inWuhan, China: a descriptive study.Lancet. 2020;395(10223):507-513.
16. Meng Y, Wang J, Wen K, et al. Clinical features and laboratoryexamination to identify severe patients with COVID-19:a systematic review and meta-analysis.Biomed Res Int.2021;21:6671291.
17. Wang Y, Zhao J, Yang L, Hu J, Yao Y. Value of the neutrophil-lymphocyte ratio in predicting COVID-19 severity: a meta-analysis.Dis Markers. 2021;2021:2571912.
18. Sinaci S, Ocal DF, Yucel Yetiskin DF, et al. Impact of vitamin Don the course of COVID-19 during pregnancy: a case control study.JSteroid Biochem Mol Biol. 2021;213:105964.
19. Oscanoa TJ, Amado J, Vidal X, Laird E, Ghashut RA, RomeroOrtuno R. The relationship between the severity and mortality ofSARS-CoV-2 infection and 25-hydroxyvitamin D concentration - ametaanalysis.Adv Respir Med. 2021;89(2):145-157.
20. Pereira M, Dantas Damascena A, Galvão Azevedo LM, Oliveira T,Santana J. Vitamin D deficiency aggravates COVID-19: systematicreview and meta-analysis.Crit Rev Food Sci Nutr. 2022;62(5):1308-1316.
21. Kazemi A, Mohammadi V, Aghababaee SK, Golzarand M, ClarkCCT, Babajafari S. Association of vitamin D status with SARS-CoV-2infection or COVID-19 severity: a systematic review and meta-analysis.Adv Nutr. 2021;12(5):2040-2044.
22. Fang X, Li S, Yu H, et al. Epidemiological, comorbidity factors withseverity and prognosis of COVID-19: a systematic review and meta-analysis.Aging (Albany NY). 2020;12(13):12493-12503.
Article available in :
Volume 2, Issue 3, 2024
Page : 51-57
https://doi.org/10.51271/JCOGP-0035
Article Information
Received : 09 Tem 2024
Accepted : 24 Tem 2024
Published : 30 Tem 2024
Corresponding Author :

Mulaim Sizer: Department of Obstetrics and Gynecology, Batman Training and Research Hospital, Batman, Turkiye

[email protected]
Citation : Değirmenci A, Ayçiçek S, Fındık FM, et al. Is vitamin D level important in pregnant women with COVID-19? J Controv Obstetr Gynecol Ped. 2024;2(3):51-57.

Read: 243
Cited: 0
Download : 76
_Footer