JCOGP
Journal of Controversies in Obstetrics & Gynecology and Pediatrics

As of January 2023, our "Journal of Controversies Obstetrics & Gynecology and Pediatrics" has been published under the Medihealth Academy to publish all articles, reviews and case reports on Pediatrics, especially in the field of Obstetrics and Gynecology. In order to facilitate the citation of the articles, to take our place in internationally respected indexes and to reach a wider readership, we will pay attention to the fact that our article language is only English in terms of acceptance.

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Original Article
Effects of long-term high-dose medroxyprogesterone acetate use on bone mineral density in postmenopausal women
Abstract
Aims: The aim of this study was to investigate the relationship between long-term depot medroxyprogesterone acetate (DMPA) use and bone mineral density (BMD) in postmenopausal women.
Methods: This study was conducted on 40 postmenopausal women who presented at the SSK Okmeydanı Training and Research Hospital Gynecology and Obstetrics Polyclinic. The sample for the study was randomly selected from postmenopausal women and divided into the control group (N=20) and the medroxyprogesterone acetate group (N=19).
Results: A total of 39 participants were included in this study, 19 cases and 20 controls. Long-term DMPA users had higher BMD compared with the control group. These differences from the control group were statistically and potentially clinically significant. The BMD in the control group has decreased significantly during one year of study. Based on the results, the longterm use of DMPA significantly affects the bone mineral density in postmenopausal women, increasing BMD.
Conclusion: Long-term use of DMPA was associated with improved BMD after treatment. The findings demonstrate the need for long-term, controlled, prospective studies with adequate sample size to evaluate the potential clinical impact of DMPA use on bone health outcomes in postmenopausal women.

Keywords : Depot medroxyprogesterone acetate, bone mineral density, osteoporosis, postmenopause, women

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Article available in :
Volume 2, Issue 4, 2024
Page : 78-82
https://doi.org/10.51271/JCOGP-0035
Article Information
Received : 04 Eyl 2024
Accepted : 01 Eki 2024
Published : 23 Eki 2024
Corresponding Author :

Altuğ Semiz: Department of Obstetrics and Gynecology, Faculty of Medicine, İstinye University, İstanbul, Turkiye

[email protected]
Citation : Semiz A. Effects of long-term high-dose medroxyprogesterone acetate use on bone mineral density in postmenopausal women. J Controv Obstetr Gynecol Ped. 2024;2(4):78-82.

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