As of January 2023, our "Journal of Controversies Obstetrics & Gynecology and Pediatrics" has been published under the Medihealth Academy to publish all articles, reviews and case reports on Pediatrics, especially in the field of Obstetrics and Gynecology. In order to facilitate the citation of the articles, to take our place in internationally respected indexes and to reach a wider readership, we will pay attention to the fact that our article language is only English in terms of acceptance.

EndNote Style
Letter to the Editor
What do we know about kisspeptin?
Kisspeptins are a group of peptide fragments that are expressed by the neurons of the hypothalamus mainly in the arcuate, dorsal-medial and antero ventricular, periventricular nuclei of the hypothalamus besides the amygdala.1 Initially, Kisspeptin via its G protein-coupled receptor 54 (GPR54) was introduced to have an important role in cancer biology with its metastasis suppression effect. In light of recent research, Kisspeptin is found to have a major role in the neuroendocrine reproductive axis through the Kisspeptin 1 (KISS1) gene. The KISS1 gene that encodes Kisspeptin was first discovered in 1996 by researchers from the United States of America. Kisspeptinreceptors are also expressed by the same neurons. Kisspeptin has a pivotal role in reproduction through the hypothalamic-hypophysial axis while exerting an extra hypothalamic function on sexual and emotional behavior.

1. Gottsch ML, Cunningham MJ, Smith JT, et al. A role for kisspeptins inthe regulation of gonadotropin secretion in the mouse. Endocrinology.2004;145(9):4073-4077. doi:10.1210/en.2004-0431
2. West A, Vojta PJ, Welch DR, Weissman BE. Chromosome localizationand genomic structure of the KiSS-1 metastasis suppressor gene(KISS1). Genomics. 1998;54(1):145-148. doi:10.1006/geno.1998.5566
3. Kauffman AS, Park JH, McPhie-Lalmansingh AA, et al. Thekisspeptin receptor GPR54 is required for sexual differentiation of thebrain and behavior. J Neurosci. 2007;27(33):8826-8835. doi:10.1523/JNEUROSCI.2099-07.2007
4. Hu KL, Chang HM, Zhao HC, Yu Y, Li R, Qiao J. Potential rolesfor the kisspeptin/kisspeptin receptor system in implantation andplacentation. Hum Reprod Update. 2019;25(3):326-343. doi:10.1093/humupd/dmy046
5. Kasum M, Franulic D, Cehic E, Oreškovic S, Lila A, Ejubovic E.Kisspeptin as a promising oocyte maturation trigger for in vitrofertilisation in humans. Gynecol Endocrinol. 2017;33(8):583-587. doi:10.1080/09513590.2017.1309019
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7. Thompson EL, Patterson M, Murphy KG, et al. Central and peripheraladministration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis. J Neuroendocrinol. 2004;16(10):850-858.doi:10.1111/j.1365-2826.2004.01240.x
8. Gaytán F, Gaytán M, Castellano JM, et al. KiSS-1 in the mammalianovary: distribution of kisspeptin in human and marmoset andalterations in KiSS-1 mRNA levels in a rat model of ovulatorydysfunction. Am J Physiol Endocrinol Metab. 2009;296(3):E520-E531.doi:10.1152/ajpendo.90895.2008
9. Saadeldin IM, Koo OJ, Kang JT, et al. Paradoxical effects of kisspeptin:it enhances oocyte in vitro maturation but has an adverse impacton hatched blastocysts during in vitro culture. Reprod Fertil Dev.2012;24(5):656-668. doi:10.1071/RD11118
10. Mumtaz A, Khalid A, Jamil Z, Fatima SS, Arif S, Rehman R.Kisspeptin: A Potential Factor for Unexplained Infertility andImpaired Embryo Implantation. Int J Fertil Steril. 2017;11(2):99-104.doi:10.22074/ijfs.2017.4957
11. Taniguchi Y, Kuwahara A, Tachibana A, et al. Intra-follicularkisspeptin levels are related to oocyte maturation and gonadalhormones in patients who are undergoing assisted reproductivetechnology. Reprod Med Biol. 2017;16(4):380-385. doi:10.1002/rmb2.12056
12. Bódis J, Sulyok E, Koszegi T, Prémusz V, Várnagy Á, Koppán M.Serum and follicular fluid levels of serotonin, kisspeptin, andbrain-derived neurotrophic factor in patients undergoing invitro fertilization: an observational study : Neurohormones inpatients receiving IVF. J Int Med Res. 2020;48(4):300060519879330.doi:10.1177/0300060519879330
13. Jayasena CN, Abbara A, Comninos AN, et al. Kisspeptin-54 triggersegg maturation in women undergoing in vitro fertilization. J ClinInvest. 2014;124(8):3667-3677. doi:10.1172/JCI75730
14. Abbara A, Jayasena CN, Christopoulos G, et al. Efficacy ofKisspeptin-54 to Trigger Oocyte Maturation in Women at HighRisk of Ovarian Hyperstimulation Syndrome (OHSS) DuringIn Vitro Fertilization (IVF) Therapy. J Clin Endocrinol Metab.2015;100(9):3322-3331. doi:10.1210/jc.2015-2332
15. Rehman R, Zafar A, Ali AA, Baig M, Alam F. Impact of serumand follicular fluid kisspeptin and estradiol on oocyte maturityand endometrial thickness among unexplained infertile femalesduring ICSI. PLoS One. 2020;15(10):e0239142. doi:10.1371/journal.pone.0239142
16. Calder M, Chan YM, Raj R, et al. Implantation failure in femaleKiss1-/- mice is independent of their hypogonadic state and canbe partially rescued by leukemia inhibitory factor. Endocrinology.2014;155(8):3065-3078. doi:10.1210/en.2013-1916
17. Jamil Z, Fatima SS, Arif S, Alam F, Rehman R. Kisspeptin and embryoimplantation after ICSI. Reprod Biomed Online. 2017;34(2):147-153.doi:10.1016/j.rbmo.2016.11.004
18. Hu KL, Chen Z, Deng W, et al. Diagnostic Value of Kisspeptin Levelson Early Pregnancy Outcome: a Systematic Review and Meta-analysis.Reprod Sci. 2022;29(12):3365-3372. doi:10.1007/s43032-022-00856-8
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21. Harrington J, Palmert MR. Clinical review: Distinguishingconstitutional delay of growth and puberty from isolatedhypogonadotropichypogonadism: critical appraisal of availablediagnostic tests. J Clin Endocrinol Metab. 2012;97(9):3056-3067.doi:10.1210/jc.2012-1598
22. Chan YM, Lippincott MF, Sales Barroso P, et al. Using Kisspeptinto Predict Pubertal Outcomes for Youth With Pubertal Delay. J ClinEndocrinol Metab. 2020;105(8):e2717-e2725. doi:10.1210/clinem/dgaa162
23. Velasco I, León S, Barroso A, et al. Gonadal hormone-dependent vs.-independent effects of kisspeptin signaling in the control of bodyweight and metabolic homeostasis. Metabolism. 2019;98:84-94.doi:10.1016/j.metabol.2019.06.007
24. Fu LY, van den Pol AN. Kisspeptin directly excitesanorexigenicproopiomelanocortin neurons but inhibits orexigenicneuropeptide Y cells by an indirect synaptic mechanism. J Neurosci.2010;30(30):10205-10219. doi:10.1523/JNEUROSCI.2098-10.2010
25. Tolson KP, Garcia C, Yen S, et al. Impaired kisspeptin signalingdecreases metabolism and promotes glucose intolerance and obesity. JClin Invest. 2014;124(7):3075-3079. doi:10.1172/JCI71075
26. Yang L, Demetriou L, Wall MB, et al. The Effects of Kisspeptin on BrainResponse to Food Images and Psychometric Parameters of Appetitein Healthy Men. J Clin Endocrinol Metab. 2021;106(4):e1837-e1848.doi:10.1210/clinem/dgaa746
27. Pineda R, Plaisier F, Millar RP, Ludwig M. Amygdala KisspeptinNeurons: Putative Mediators of Olfactory Control of theGonadotropic Axis. Neuroendocrinology. 2017;104(3):223-238.doi:10.1159/000445895
28. Goldsammler M, Merhi Z, Buyuk E. Role of hormonal andinflammatory alterations in obesity-related reproductive dysfunctionat the level of the hypothalamic-pituitary-ovarian axis. Reprod BiolEndocrinol. 2018;16(1):45. doi:10.1186/s12958-018-0366-6
Volume 1, Issue 2, 2023
Page : 51-53