As of January 2023, our "Journal of Controversies Obstetrics & Gynecologyand Pediatrics" has been published under the Medihealth Academy to publish all articles, reviews and case reports on Pediatrics, especially in the field of Obstetrics and Gynecology. In order to facilitate the citation of the articles, to take our place in internationally respected indexes and to reach a wider readership, we will pay attention to the fact that our article language is only English in terms of acceptance.

Original Article
The effect of thyroid autoimmunity on early pregnancy serum ß-hCG levels in spontaneous pregnancy
Aims: To examine the association between thyroid autoimmunity (TAI) and early pregnancy serum beta human chorionic gonadotropin (ß-hCG) levels in spontaneous pregnancy.
Methods: In this retrospective case-control study, women between the ages of 20 and 40 were included. The study subjects were 130 women euthyroid and healthy patients with spontaneous pregnancy. Subjects were divided into two groups: those with autoimmune thyroid disease (TAI group; n=60) and those without the disease (control group; n=70).
Results: The mean age and body mass index (BMI) of the subjects were 30.22±4.14 years and 24.51±2.04, respectively. The value of anti-thyroid peroxidase antibodies (TPO-Abs) and anti-thyroglobulin antibodies (TG-Abs) in the TAI group is three times twenty times more than the control, respectively. Results found no statistically significant association between between TAI and control groups in regard to hemoglobin, alanine transaminase (ALT), aspartate transaminase (AST), thyroid-stimulating hormone (TSH), platelet (PLT), creatine, free thyroxin (FT4), and blood urea nitrogen (BUN) (p>0.05). There was statistically significant difference between groups in terms of the serum ß-hCG level (p<0.05).
Conclusion: In this study, the effects of TAI were significant on early-stage pregnancy serum ß-hCG levels; therefore, thyroid levels should be considered, and proper treatment should be started early.

1. Gungor K, Dokuzeylul Gungor N. Antithyroid antibodies maypredict serum beta HCG levels and biochemical pregnancy losses ineuthyroid women with IVF single embryo transfer. Gynecol Endocrinol.2021;37(8):702-705. doi:10.1080/09513590.2020.1830968
2. Rahnama R, Mahmoudi AR, Kazemnejad S, et al. Thyroid peroxidasein human endometrium and placenta: a potential target for anti-TPOantibodies. Clin Exp Med. 2021;21(1):79-88. doi:10.1007/s10238-020-00663-y
3. Krassas GE, Perros P, Kaprara A. Thyroid autoimmunity, infertilityand miscarriage. Expert Rev Endocrinol Metab. 2008;3(2):127-136.doi:10.1586/17446651.3.2.127
4. Heshmati HM, Fatourechi V. Abstract# 1181020: Hashimoto&rsquo;sThyroiditis and Primary Thyroid Lymphoma. Endocrine Practice 2022;28 (5): S143. doi:10.1016/j.eprac.2022.03.334
5. Fr&ouml;hlich E, Wahl R. Thyroid Autoimmunity: Role of Anti-thyroidAntibodies in Thyroid and Extra-Thyroidal Diseases. Front Immunol.2017;8:521. doi:10.3389/fimmu.2017.00521
6. Ayar Madenli A. , &Ouml;z İ. , G&uuml;rb&uuml;z T. The relationship between antimullerian hormone level and endometrial polyp frequency in patientswith polycystic ovary syndrome. J Med Palliat Care. 2022; 3(3): 263-267.doi: 10.47582/jompac.1148111
7. Benvenga S, Elia G, Ragusa F, et al. Endocrine disruptors and thyroidautoimmunity. Best Pract Res Clin Endocrinol Metab. 2020;34(1):101377.doi:10.1016/j.beem.2020.101377
8. G&uuml;ng&ouml;r ND, G&uuml;rb&uuml;z T. Prediction of the number of oocytes based onAMH and FSH levels in IVF candidates. J Surg Med. 2020; 4 (9): 733-7.doi:10.28982/josam.759207.
9. Mazzilli R, Medenica S, Di Tommaso AM, et al. The role of thyroidfunction in female and male infertility: a narrative review. J EndocrinolInvest. 2023;46(1):15-26. doi:10.1007/s40618-022-01883-7
10. Gungor ND, Gurbuz T. Pregnancy Outcomes of IntrauterineInsemination in Age-Matched Young Women According to SerumAnti-Mullerian Hormone Levels. JRM 2021; 66: 195-202.
11. van den Boogaard E, Vissenberg R, Land JA, et al. Significance of(sub)clinical thyroid dysfunction and thyroid autoimmunity beforeconception and in early pregnancy: a systematic review. Hum ReprodUpdate. 2011;17(5):605-619. doi:10.1093/humupd/dmr024
12. Vissenberg R, Manders VD, Mastenbroek S, et al. Pathophysiologicalaspects of thyroid hormone disorders/thyroid peroxidaseautoantibodies and reproduction. Hum Reprod Update. 2015;21(3):378-387. doi:10.1093/humupd/dmv004
13. Medenica S, Abazovic D, Ljubic A, et al. The Role of Cell and GeneTherapies in the Treatment of Infertility in Patients with ThyroidAutoimmunity. Int J Endocrinol. 2022;2022:4842316. Published 2022Aug 30. doi:10.1155/2022/4842316
14. Butts SF, Guo W, Cary MS, et al. Predicting the decline in humanchorionic gonadotropin in a resolving pregnancy of unknownlocation. Obstet Gynecol. 2013;122(2Pt1):337-343. doi:10.1097/AOG.0b013e31829c6ed6
15. Yu H, Liu J, Guo H, Chen C, Han Y, Cui Y. Prognostic value of repeatedserum kisspeptin measurements in early first trimester pregnancy:a preliminary study. Reprod Biomed Online. 2019;38(3):465-471.doi:10.1016/j.rbmo.2018.11.014
16. Rao M, Zeng Z, Zhang Q, et al. Thyroid Autoimmunity Is NotAssociated with Embryo Quality or Pregnancy Outcomes in EuthyroidWomen Undergoing Assisted Reproductive Technology in China.Thyroid. 2023;10.1089/thy.2022.0184. doi:10.1089/thy.2022.0184
17. Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analysesusing G*Power 3.1: tests for correlation and regression analyses. BehavRes Methods. 2009;41(4):1149-1160. doi:10.3758/BRM.41.4.1149
18. Al Mamari N, Al Zawawi N, Khayat S, Badeghiesh A, Son WY, DahanMH. Revisiting serum &beta;-hCG cut-off levels and pregnancy outcomesusing single embryo transfer. J Assist Reprod Genet. 2019;36(11):2307-2313. doi:10.1007/s10815-019-01583-x
19. Ajmani NS, Sarbhai V, Yadav N, Paul M, Ahmad A, Ajmani AK.Role of Thyroid Dysfunction in Patients with Menstrual Disorders inTertiary Care Center of Walled City of Delhi. J Obstet Gynaecol India.2016;66(2):115-119. doi:10.1007/s13224-014-0650-0
20. Koyyada A, Orsu P. Role of hypothyroidism and associated pathwaysin pregnancy and infertility: Clinical insights. Tzu Chi Med J.2020;32(4):312-317. doi:10.4103/tcmj.tcmj_255_19
21. Aghajanova L, Lindeberg M, Carlsson IB, et al. Receptors for thyroid-stimulating hormone and thyroid hormones in human ovariantissue. Reprod Biomed Online. 2009;18(3):337-347. doi:10.1016/s1472-6483(10)60091-0
22. Beneventi F, De Maggio I, Bellingeri C, et al. Thyroid autoimmunity andadverse pregnancy outcomes: a prospective cohort study. Endocrine.2022;76(1):198-207. doi:10.1007/s12020-021-02958-w
23. Moleti M, Sturniolo G, Di Mauro M, Russo M, Vermiglio F.Autoimmune thyroid diseases and pregnancy. Ann Thyroid. 2018;3:18.doi: 10.21037/aot.2018.07.03
24. Huget-Penner S, Feig DS. Maternal thyroid disease and its effects onthe fetus and perinatal outcomes. Prenat Diagn. 2020;40(9):1077-1084.doi:10.1002/pd.5684
25. Toloza FJK, Derakhshan A, M&auml;nnist&ouml; T, et al. Association betweenmaternal thyroid function and risk of gestational hypertension and pre-eclampsia: a systematic review and individual-participant data meta-analysis. Lancet Diabetes Endocrinol. 2022;10(4):243-252. doi:10.1016/S2213-8587(22)00007-9
26. Sitoris G, Veltri F, Kleynen P, et al. The Impact of Thyroid Disorders onClinical Pregnancy Outcomes in a Real-World Study Setting. Thyroid.2020;30(1):106-115. doi:10.1089/thy.2019.0199
27. Busnelli A, Paffoni A, Fedele L, Somigliana E. The impact of thyroidautoimmunity on IVF/ICSI outcome: a systematic review and meta-analysis [published correction appears in Hum Reprod Update.2016 Nov;22(6):793-794]. Hum Reprod Update. 2016;22(6):775-790.doi:10.1093/humupd/dmw019
28. Dosiou C. Thyroid and Fertility: Recent Advances. Thyroid.2020;30(4):479-486. doi:10.1089/thy.2019.0382
29. Dokuzeyl&uuml;l G&uuml;ng&ouml;r N, G&uuml;ng&ouml;r K, Celik N, &Ouml;nal M, Madenli AA.Impact of body mass index and vitamin D on serum AMH levelsand antral follicle count in PCOS. Eur Rev Med Pharmacol Sci.2023;27(1):179-187. doi:10.26355/eurrev_202301_30870
30. d&rsquo;Hauterive SP, Close R, Gridelet V, Mawet M, Nisolle M, Geenen V.Human Chorionic Gonadotropin and Early Embryogenesis: Review.Int J Mol Sci. 2022;23(3):1380. Published 2022 Jan 26. doi:10.3390/ijms23031380
31. Krishnan N, Yadev I, Anandan J, Patra D, Rajan A, Srinivas P.Pregnancy Hormone Mediated Tumorigenesis in BRCA1 DefectiveBreast Cancers. The FASEB Journal. 2022;36.
32. Liu Y, Guo F, Maraka S, et al. Associations between Human ChorionicGonadotropin, Maternal Free Thyroxine, and Gestational DiabetesMellitus. Thyroid. 2021;31(8):1282-1288. doi:10.1089/thy.2020.0920
33. Korevaar TI, Steegers EA, Pop VJ, et al. Thyroid Autoimmunity Impairsthe Thyroidal Response to Human Chorionic Gonadotropin: TwoPopulation-Based Prospective Cohort Studies. J Clin Endocrinol Metab.2017;102(1):69-77. doi:10.1210/jc.2016-2942
Volume 1, Issue 2, 2023
Page : 41-45