JCOGP
Journal of Controversies in Obstetrics & Gynecology and Pediatrics

As of January 2023, our "Journal of Controversies Obstetrics & Gynecology and Pediatrics" has been published under the Medihealth Academy to publish all articles, reviews and case reports on Pediatrics, especially in the field of Obstetrics and Gynecology. In order to facilitate the citation of the articles, to take our place in internationally respected indexes and to reach a wider readership, we will pay attention to the fact that our article language is only English in terms of acceptance. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

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Original Article
Investigation of the correlation of prognostic parameters in cases of endometrium carcinoma
Abstract
Aims: Endometrial carcinoma is the most common gynecological cancer in developed countries and the second most common in Turkey. Due to its significant impact on survival rates, recurrence rates, as well as treatment and post-treatment approaches, identifying and studying prognostic factors is of great importance. This article aims to review the prognostic parameters established for endometrial carcinoma and investigate the studies and findings related to these parameters.
Methods: The study included 50 patients who underwent surgery for endometrial carcinoma at our clinic between January 1999 and May 2001. Investigations and results related to prognostic factors in endometrial carcinoma were examined in these patients.
Results: The average age of the patients was found to be 56.72 ± 8.02 years. %70 of the patients were in Stage 1, 6% were in Stage 2, 22% were in Stage 3, and the remaining 2% were in Stage 4. Peritoneal cytology was positive in 5 out of 41 patients in whom peritoneal cytology was examined (12.2%). Among the 49 patients evaluated for myometrial invasion, 11 had tumor confined to the endometrium without myometrial invasion. In 16 patients, there was 1/3 inner myometrial invasion, 15 patients had 1/3 middle myometrial invasion, and 7 patients had 1/3 outer myometrial invasion. When we compared grade and depth of myometrial invasion in the cases examined, it was observed that out of 17 patients with Grade 1 tumors, 1 had deep myometrial invasion (½ outside), while out of 22 patients with Grade 2 tumors, 8 had deep myometrial invasion, and out of 4 patients with Grade 3 tumors, 3 had deep myometrial invasion.
Conclusion: The results of the examination of prognostic parameters, including age, histological grade, myometrial invasion, peritoneal cytology, histological type, adnexal spread, and tumor size, in the studied patient group were consistent with previous research in this field.

Keywords : Endometrial carcinoma, age, prognosis, cancer, prognostic parameters

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1. Kurman RJ, Carcangiu ML, Herrington CS, Young RH. WHOClassification Tumours of Female Reproductive Organs. 4th ed.IARC:2014:124-154.
2. T.C Sağlık Bakanlığı Halk Sağlığı Müdürlüğü. Türkiye kanseristatistikleri 2016. 2019; Available from: https://hsgm.saglik.gov.t r/depo/ bi r i m ler/ kanserdb/istat ist i k / Trk iye _ K a nser_statistikleri_2016.pdf
3. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM.Estimates of worldwide burden of cancer in 2008: GLOBOCAN2008. Int J Cancer. 2010;127(12):2893-2917. doi:10.1002/ijc.25516
4. Steinbakk A, Malpica A, Slewa A, et al. Biomarkers and microsatelliteinstability analysis of curettings can predict the behavior of FIGOstage I endometrial endometrioid adenocarcinoma. Mod Pathol.2011;24(9):1262-1271. doi:10.1038/modpathol.2011.75
5. Rock JA, Thompson JD. Malignant tumors of the uterin corpus,incidence. Te Linde’s Operat Gynecol. 1997;50:1503.
6. Crissman JD, Azoury RS, Barnes AE, Schellhas HF. Endometrialcarcinoma in women 40 years of age or younger. Obstet Gynecol.1981;57(6):699-704.
7. Christopherson WM, Connelly PJ, Alberhasky RC. Carcinoma ofthe endometrium. V. an analysis of prognosticators in patients withfavorable subtypes and Stage I disease. Cancer. 1983;51(9):1705-1709.
8. Nilsen PA, Koller O. Carcinoma of the endometrium in Norway1957-1960 with special reference to treatment results. Am J ObstetGynecol. 1969;105(7):1099-1109. doi:10.1016/0002-9378(69)90133-1
9. Lurain JR, Rice BL, Rademaker AW, Poggensee LE, Schink JC,Miller DS. Prognostic factors associated with recurrence in clinicalstage I adenocarcinoma of the endometrium. Obstet Gynecol.1991;78(1):63-69.
10. Baltzer J, Lohe KJ. Pathologie. Diagnostic und Behandlung desEndometriumkarzinoms und seiner Vorstufen. In: Kaser O,Friedberg V, Ober KG, Thomsen K, Zander J, eds. Gynakologie undGeburtshilfe. Stuttgard: 1988:3:101.
11. Chambers SK, Kapp DS, Peschel RE, et al. Prognostic factors andsites of failure in FIGO stage I, grade 3 endometrial carcinoma.Gynecol Oncol. 1987;27(2):180-188.
12. Wharton JT, Mikuta JJ, Mettlin C, et al. Risk factors and currentmanagement in carcinoma of the endometrium. Surg GynecolObstet. 1986;162(6):515-520.
13. Boronow RC, Morrow CP, Creasman WT, et al. Surgical staging inendometrial cancer: clinical-pathologic findings of a prospectivestudy. Obstet Gynecol. 1984;63(6):825-832.
14. Turner DA, Gershenson DM, Atkinson N, Sneige N, WhartonAT. The prognostic significance of peritoneal cytology for stage Iendometrial cancer. Obstet Gynecol. 1989;74(5):775-780.
15. Schink JC, Lurain JR, Wallemark CB, Chmiel JS. Tumor size inendometrial cancer: a prognostic factor for lymph node metastasis.Obstet Gynecol. 1987;70(2):216-219.
16. Schink JC, Rademaker AW, Miller DS, Lurain JR. Tumor size inendometrial cancer. Cancer. 1991;67(11):2791-2794.
17. Bucy GS, Mendenhall WM, Morgan LS, et al. Clinical stageI and II endometrial carcinoma treated with surgery and/orradiation therapy: analysis of prognostic and treatment-relatedfactors. Gynecol Oncol. 1989;33(3):290-295. doi:10.1016/0090-8258(89)90514-3
18. Aalders J, Abeler V, Kolstad P, Onsrud M. Postoperative externalirradiation and prognostic parameters in stage I endometrialcarcinoma: clinical and histopathologic study of 540 patients.Obstet Gynecol. 1980;56(4):419-427.
19. Gokmen Karasu AF, Ates S, Gurbuz T, Sahin N, Takmaz T, AydinS. A clinico-pathological study of transvaginal endometrialthickness measurement in asymptomatic postmenopausal patientsand patients with postmenopausal bleeding. Gynecol Obstet ReprodMed. 2019;25(2):85-88. doi:10.21613/GORM.2018.851
20. Creasman WT, Rutledge F. The prognostic value of peritonealcytology in gynecologic malignant disease. Am J Obstet Gynecol.1971;110(6):773-781. doi:10.1016/0002-9378(71)90571-0
Article available in :
Volume 2, Issue 1, 2024
Page : 1-6
https://doi.org/10.51271/JCOGP-0024
Article Information
Received : 05 Kas 2023
Accepted : 29 Kas 2023
Published : 29 Oca 2024
Corresponding Author :

Nurgül Ulusoy: Private Gynecology and Obstetric Clinic, İstanbul, Turkiye

[email protected]
Citation : Ulusoy N, Gülkılık A. Investigation of the correlation of prognostic parameters in cases of endometrium carcinoma. J Controv Obstetr Gynecol Ped. 2024;2(1):1-6.

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