JCOGP
Journal of Controversies in Obstetrics & Gynecology and Pediatrics

As of January 2023, our "Journal of Controversies Obstetrics & Gynecology and Pediatrics" has been published under the Medihealth Academy to publish all articles, reviews and case reports on Pediatrics, especially in the field of Obstetrics and Gynecology. In order to facilitate the citation of the articles, to take our place in internationally respected indexes and to reach a wider readership, we will pay attention to the fact that our article language is only English in terms of acceptance. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

eISSN: 2980-0579
Creative Commons CC BY-NC-ND 4.0 International License.
EndNote Style

Online Manuscript System

Index
Original Article
Does autoimmune disease affect in vitro fertilization results in normo-responder cases?
Abstract
Aims: This study aimed to assess the effects of autoimmune disorders on pregnancy outcomes in infertile women undergoing in vitro fertilization (IVF) treatment.
Methods: This retrospective cohort study was conducted between March 2022 and September 2023, involving 90 infertile women without autoimmune diseases as a control group and 96 infertile women with autoimmune diseases as a case group. The study investigated the impact of autoimmune diseases on IVF treatment outcomes. Single embryo transfer (ET) was performed on the fifth day in all patients. Autoimmune diseases included in this study as Hashimoto's disease, Rheumatoid Arthritis, Sjogren's syndrome, Systemic lupus erythematosus (SLE), Ulcerative Colitis, and Behcet's disease.
Results: There was no statistically significant association between the case and control groups regarding live birth rate (p>0.05). Similarly, no statistically significant association was found between the case and control groups concerning the clinical pregnancy rate (p>0.05). Our results revealed that total oocyte, pronuclear (PN), and metaphase II (MII) oocyte rates were statistically significantly higher in healthy infertile women (p<0.05). The number of attempts, anti mullerian (AMH) levels, total gonadotropin dose, and total days were similar between the groups (p>0.05).
Conclusion: Autoimmune diseases do not significantly affect pregnancy outcomes in women undergoing IVF. However, several factors, such as total oocyte, PN, and MII oocytes, clinical pregnancy rate (CPR), and live birth rate (LBR) levels, support the association between autoimmune diseases and IVF outcomes.

Keywords : Autoimmune disease, clinical pregnancy rate, in vitro fertilization, pregnancy outcomes, infertility

Download Article


1. Gungor K, Dokuzeylul Gungor N. Antithyroid antibodies maypredict serum beta HCG levels and biochemical pregnancy lossesin euthyroid women with IVF single embryo transfer. GynecolEndocrinol. 2021;37(8):702-705. doi:10.1080/09513590.2020.1830968
2. Ferber S, Marks NJ, Mackie V. IVF and Assisted Reproduction: AGlobal History. Palgrave Macmillan Singapore: 2020.
3. Dokuzeyl&uuml;l G&uuml;ng&ouml;r N, G&uuml;ng&ouml;r K, Celik N, &Ouml;nal M, Madenli AA.Impact of body mass index and vitamin D on serum AMH levelsand antral follicle count in PCOS. Eur Rev Med Pharmacol Sci.2023;27(1):179-187. doi:10.26355/eurrev_202301_30870
4. Ağar M, G&uuml;ng&ouml;r K, G&uuml;ng&ouml;r ND, Kavrut M, Madenli AA. Vitamin Dsupplementation inhibits NF-k&szlig; signaling pathway in lean and obesewomen with PCOS. Eur Rev Med Pharmacol Sci. 2022;26(11):3973-3977. doi:10.26355/eurrev_202206_28967
5. Dokuzeyl&uuml;l G&uuml;ng&ouml;r N, G&uuml;ng&ouml;r K, Yurci A, Cil K, Hatırnaz Ş.Ovarian drilling down-regulates endometrial nuclear factor-&kappa;Bp65 expression in women with PCOS: a prospective case-controlstudy. Turk J Obstet Gynecol. 2022;19(1):45-50. doi:10.4274/tjod.galenos.2022.44845
6. Jarne-Borr&agrave;s M, Mir&oacute;-Mur F, Anunciaci&oacute;n-Llunell A, Alijotas-Reig J. Antiphospholipid antibodies in women with recurrentembryo implantation failure: a systematic review and meta-analysis.Autoimmun Rev. 2022;21(6):103101. doi:10.1016/j.autrev.2022.103101
7. Jain M, Singh M. Assisted Reproductive Technology (ART)Techniques. [Updated 2023 Jun 7]. In: StatPearls [Internet]. TreasureIsland (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK576409/
8. G&uuml;ng&ouml;r ND, G&uuml;rb&uuml;z T. Prediction of the number of oocytes based onAMH and FSH levels in IVF candidates. JOSAM. 2020;4(9):733-737.doi: 10.28982/josam.759207
9. Dokuzeylul Gungor N, Gurbuz T, Ture T. Prolonged luteal phasesupport with progesterone may increase papules and plaques ofpregnancy frequency in pregnancies through in vitro fertilization.An Bras Dermatol. 2021;96(2):171-175. doi:10.1016/j.abd.2020.09.002
10. Viswanath D. Understanding autoimmune diseases-a review. IOSR JDental Med Sci. 2013;6(6):08-15.
11. Cooper GS, Bynum ML, Somers EC. Recent insights in theepidemiology of autoimmune diseases: improved prevalenceestimates and understanding of clustering of diseases. J Autoimmun.2009;33(3-4):197-207. doi:10.1016/j.jaut.2009.09.008
12. Moran CA, Collins LF, Beydoun N, et al. Cardiovascular implicationsof immune disorders in women. Circ Res. 2022;130(4):593-610.doi:10.1161/CIRCRESAHA.121.319877
13. Desai MK, Brinton RD. Autoimmune disease in women: endocrinetransition and risk across the lifespan. Front Endocrinol. 2019;10:265.doi:10.3389/fendo.2019.00265
14. Somers EC, Thomas SL, Smeeth L, Schoonen WM, Hall AJ. Incidenceof systemic lupus erythematosus in the United Kingdom, 1990-1999.Arthritis Rheum. 2007;57(4):612-618. doi:10.1002/art.22683
15. De Carolis S, Moresi S, Rizzo F, et al. Autoimmunity in obstetricsand autoimmune diseases in pregnancy. Best Pract Res Clin ObstetGynaecol. 2019;60:66-76. doi:10.1016/j.bpobgyn.2019.03.003
16. Khizroeva J, Nalli C, Bitsadze V, et al. Infertility in women withsystemic autoimmune diseases. Best Pract Res Clin Endocrinol Metab.2019;33(6):101369. doi:10.1016/j.beem.2019.101369
17. Yurci A, Dokuzeylul Gungor N, Gurbuz T. Spectroscopy analysis ofendometrial metabolites is a powerful predictor of success of embryotransfer in women with implantation failure: a preliminary study. GynecolEndocrinol. 2021;37(5):415-421. doi:10.1080/09513590.2021.1883584
18. Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses usingG*Power 3.1: tests for correlation and regression analyses. Behav ResMethods. 2009;41(4):1149-1160. doi:10.3758/BRM.41.4.1149
19. Irure-Ventura J, L&oacute;pez-Hoyos M. The past, present, and future inantinuclear antibodies (ANA). Diagnostics. 2022;12(3):647. doi:10.3390/diagnostics12030647
20. Berestoviy VO, Mahmood AA, Berestoviy OO, Ginzburg VG, GovsieievDO. An overview of autoimmunity in implantation failure: a literaturereview. Wiad Lek. 2021;74(3 p.II):777-783.
21. Chen X, Mo ML, Huang CY, et al. Association of serum autoantibodieswith pregnancy outcome of patients undergoing first IVF/ICSItreatment: a prospective cohort study. J Reprod Immunol. 2017;122:14-20.doi:10.1016/j.jri.2017.08.002
22. Li Y, Wang Y, Lan Y, Zhang J, Liang Y, Wang S. Antinuclear antibodiesin follicular fluid may reduce efficacy of in vitro fertilization and embryotransfer by invading endometrium and granular cells. Am J ReprodImmunol. 2020;84(4):e13289. doi:10.1111/aji.13289
23. Li Y, Wang Y, Ma Y, et al. Investigation of the impact of antinuclearantibody on the outcome of in vitro fertilization/intracytoplasmicsperm injection treatment. Taiwan J Obstet Gynecol. 2015;54(6):742-748.doi:10.1016/j.tjog.2015.09.001
24. Zhu Q, Wu L, Xu B, et al. A retrospective study on IVF/ICSI outcome inpatients with anti-nuclear antibodies: the effects of prednisone plus low-dose aspirin adjuvant treatment. Reprod Biol Endocrinol. 2013;11(1):98.doi:10.1186/1477-7827-11-98
25. Ying Y, Zhong YP, Zhou CQ, et al. A further exploration of the impact ofantinuclear antibodies on in vitro fertilization-embryo transfer outcome.Am J Reprod Immunol. 2013;70(3):221-229. doi:10.1111/aji.12111
26. Ticconi C, Inversetti A, Logruosso E, et al. Antinuclear antibodiespositivity in women in reproductive age: from infertility toadverse obstetrical outcomes - a meta-analysis. J Reprod Immunol.2023;155:103794. doi:10.1016/j.jri.2022.103794
27. Busnelli A, Paffoni A, Fedele L, Somigliana E. The impact of thyroidautoimmunity on IVF/ICSI outcome: a systematic review and meta-analysis. Hum Reprod Update. 2016;22(6):775-790. doi:10.1093/humupd/dmw019
28. Weghofer A, Himaya E, Kushnir VA, Barad DH, Gleicher N. The impactof thyroid function and thyroid autoimmunity on embryo quality inwomen with low functional ovarian reserve: a case-control study. ReprodBiol Endocrinol. 2015;13(1):43. doi:10.1186/s12958-015-0041-0
29. Bliddal S, Nielsen HS. Is thyroid autoimmunity still a risk factor ineuthyroid women undergoing fertility treatment? Clin Thyroidol.2023;35(2):42-44.
30. Rao M, Zeng Z, Zhang Q, et al. Thyroid autoimmunity is not associatedwith embryo quality or pregnancy outcomes in euthyroid womenundergoing assisted reproductive technology in China. Thyroid.2023;33(3):380-388. doi:10.1089/thy.2022.0184
31. Hamad A, Alhalabi N, Nmr N, et al. Impact of thyroid autoimmunity ineuthyroid women on the outcomes of in vitro fertilization. Ann Med Surg(Lond). 2021;67:102473. doi:10.1016/j.amsu.2021.102473
Article available in :
Volume 2, Issue 1, 2024
Page : 19-23
https://doi.org/10.51271/JCOGP-0028
Article Information
Received : 27 Ara 2023
Accepted : 16 Oca 2024
Published : 29 Oca 2024
Corresponding Author :

Halime Çalı Öztürk: Bezmialem University, Department of Obstetrics and Gynecology, Istanbul, Turkey

[email protected]
Citation : Ağar M, Devranoğlu B, Çalı Öztürk H. Does autoimmune disease affect in vitro fertilization results in normo-responder cases?. J Controv Obstetr Gynecol Ped. 2024;2(1):19-23.

Read: 413
Cited: 0
Download : 230
_Footer