As of January 2023, our "Journal of Controversies Obstetrics & Gynecology and Pediatrics" has been published under the Medihealth Academy to publish all articles, reviews and case reports on Pediatrics, especially in the field of Obstetrics and Gynecology. In order to facilitate the citation of the articles, to take our place in internationally respected indexes and to reach a wider readership, we will pay attention to the fact that our article language is only English in terms of acceptance. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

EndNote Style
Original Article
Investigating the association between hyperprolactinemia and thyroid autoimmunity in women
Aims: Hyperprolactinemia (HPRL), a condition characterized by elevated levels of prolactin (PRL) hormone, is considered to be related to various autoimmune diseases, such as thyroid autoimmunity (TAI). The association between HPRL and TAI still evokes controversy. Our study intends to examine the possible relationship between HPL and TAI in young women.
Methods: This retrospective study was done between January 2018 and December 2022, including 90 women with HPRL and 90 control subjects of similar age and gender. A retrospective examination was conducted on the medical records of 90 patients with HPRL to gather relevant data. Information regarding related parameters was analyzed and compared to the control group data.
Results: Our results found that thyroid stimulating hormone (TSH) levels were notably elevated in patients with HPRL compared to healthy women (2.24 vs. 1.86). Also, a statistically significant association between the case and control regarding serum free triiodothyronine (fT3) (p<0.05). No statistically significant difference was found between the case and control regarding serum free thyroxin (fT4) (p>0.05). Patients with HPRL demonstrated considerably higher anti thyroperoxidase antibody (anti-TPO) levels (46.08 vs. 43.95). Significantly elevated antithyroglobulin antibody (anti-Tg) levels were observed in patients with HPRL (1.07 vs. 0.84).
Conclusion: The study suggests a potential link between HPRL and TAI. Further research is needed to explore this relationship and its implications for patient care.

1. Ghoreshi ZA, Akbari H, Sharif-Zak M, Arefinia N, Abbasi-JorjandiM, Asadikaram G. Recent findings on hyperprolactinemia andits pathological implications: a literature review. J Investig Med.2022;70(7):1443-1451. doi:10.1136/jim-2022-002351
2. Gungor K, Dokuzeylul Gungor N. Antithyroid antibodies maypredict serum beta HCG levels and biochemical pregnancy losses ineuthyroid women with IVF single embryo transfer. Gynecol Endocrinol.2021;37(8):702-705. doi: 10.1080/09513590.2020.1830968.
3. Ko&ccedil; Ş,G&uuml;ng&ouml;r K, Dokuzeyl&uuml;l G&uuml;ng&ouml;r N, Uzunlulu M. Iron deficiencyin women with thyroid-specific autoantibodies: a case-control study. JExp Clin Med. 2022; 39(1): 194-198 doi: 10.52142/omujecm.39.1.38
4. Godines-Enriquez MS, Miranda-Vel&aacute;squez S, Enr&iacute;quez-P&eacute;rez MMet al. Prevalence of thyroid autoimmunity in women with recurrentpregnancy loss. Medicina (Kaunas). 2021;57(2):96. doi:10.3390/medicina57020096
5. Khizroeva J, Nalli C, Bitsadze V, et al. Infertility in women withsystemic autoimmune diseases. Best Pract Res Clin Endocrinol Metab.2019;33(6):101369. doi:10.1016/j.beem.2019.101369
6. Laway BA, Sahu D, Bhat MH, et al. Thyroid autoimmunity andsubclinical hypothyroidism in prolactinoma: a case control study. IndianJ Endocrinol Metab. 2023;27(1):45-49. doi:10.4103/ijem.ijem_425_21
7. Sayki Arslan M, Sahin M, Topaloglu O, et al. Hyperprolactinaemiaassociated with increased thyroid volume and autoimmune thyroiditisin patients with prolactinoma. Clin Endocrinol (Oxf). 2013;79(6):882-886. doi:10.1111/cen.12217
8. Poyraz BC, Aksoy C, Balcioğlu I. Increased incidence of autoimmunethyroiditis in patients with antipsychotic-induced hyperprolactinemia.Eur Neuropsychopharmacol. 2008;18(9):667-672. doi:10.1016/j.euroneuro.2008.04.014
9. Yahyaoui AE, Asma K, Abdelghani KB et al. Hyperprolactinemia andconnective tissue diseases: which significance of such exceptionalassociation? in Endocrine Abstracts. Bioscientifica 2022.
10. Sahu J K, Ravikant M, Thakur AS. Hyperprolactinemia in patients withhigh TSH levels with both clinical and subclinical hypothyroidism.Panacea J Med Sci. 2022;12(1):134-137.
11. Kumari DM, Ekka BR, Kumar S. Serum prolactin, thyroid stimulatinghormone and thyroid hormones (FT3, FT4) concentrations in femalepatients with infertility: an institutional study. 2020.
12. Onal ED, Saglam F, Sacikara M, Ersoy R, Cakir B. Thyroidautoimmunity in patients with hyperprolactinemia: an observationalstudy. Arq Bras Endocrinol Metabol. 2014;58(1):48-52. doi:10.1590/0004-2730000002846
13. Venables A, Wong W, Way M, Homer HA. Thyroid autoimmunity andIVF/ICSI outcomes in euthyroid women: a systematic review and meta-analysis. Reprod Biol Endocrinol. 2020;18(1):120. doi:10.1186/s12958-020-00671-3
14. Korevaar TIM, M&iacute;nguez-Alarc&oacute;n L, Messerlian C, et al. Associationof thyroid function and autoimmunity with ovarian reserve in womenseeking infertility care. Thyroid. 2018;28(10):1349-1358. doi:10.1089/thy.2017.0582
15. Ruggeri RM, Trimarchi F. Iodine nutrition optimization: are there risksfor thyroid autoimmunity? J Endocrinol Invest. 2021;44(9):1827-1835.doi:10.1007/s40618-021-01548-x
16. Benvenga S, Antonelli A, Vita R. Thyroid nodules and thyroidautoimmunity in the context of environmental pollution. Rev EndocrMetab Disord. 2015;16(4):319-340. doi:10.1007/s11154-016-9327-6
17. Cengiz H, Demirci T, Varim C, Tamer A. The effect of Thyroid autoimmunityon dyslipidemia in patients with euthyroid hashimoto thyroiditis. Pak J MedSci. 2021;37(5):1365-1370. doi:10.12669/pjms.37.5.3883
18. Kim HJ, Park SJ, Park HK, Byun DW, Suh K, Yoo MH. Thyroidautoimmunity and metabolic syndrome: a nationwide population-basedstudy. Eur J Endocrinol. 2021;185(5):707-715. doi:10.1530/EJE-21-0634
19. Ewerman L, Landberg E, Hellberg S, et al. Immunomodulating effectsdepend on prolactin levels in patients with hyperprolactinemia. HormMetab Res. 2020;52(4):228-235. doi:10.1055/a-1126-4272
20. Rosato F, Garofalo P. Le iperprolattinemie: dalla diagnosi al trattamento[Hyperprolactinemia: from diagnosis to treatment]. Minerva Pediatr. 2002;54(6):547-552.
21. Orbach H, Shoenfeld Y. Hyperprolactinemia and autoimmune diseases.Autoimmun Rev. 2007;6(8):537-542. doi:10.1016/j.autrev.2006.10.005
22. Borba VV, Sharif K, Shoenfeld Y. Prolactin and the mosaic ofautoimmunity, in mosaic of autoimmunity. Elsevier. 2019; 435-447.
23. Borba VV, Zandman-Goddard G, Shoenfeld Y. Prolactin andautoimmunity: the hormone as an inflammatory cytokine. Best Pract ResClin Endocrinol Metab. 2019;33(6):101324. doi:10.1016/j.beem.2019.101324
24. Borba VV, Zandman-Goddard G, Shoenfeld Y. Prolactin andAutoimmunity. Front Immunol. 2018;9:73. doi:10.3389/fimmu.2018.00073
25. Bosnic Z, &Scaron;aric B, Vucic D, et al. Alopecia in preexisting autoimmunethyroid disease in family medicine practice: can hyperprolactinemiainduce hair loss? a case report. Acta Dermatovenerol Alp PannonicaAdriat. 2021;30(2):75-77.
Volume 1, Issue 4, 2023
Page : 99-103