JCOGP
Journal of Controversies in Obstetrics & Gynecology and Pediatrics

As of January 2023, our "Journal of Controversies Obstetrics & Gynecology and Pediatrics" has been published under the Medihealth Academy to publish all articles, reviews and case reports on Pediatrics, especially in the field of Obstetrics and Gynecology. In order to facilitate the citation of the articles, to take our place in internationally respected indexes and to reach a wider readership, we will pay attention to the fact that our article language is only English in terms of acceptance.

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Original Article
Evaluation of hemogram parameters in patients with atopic dermatitis
Abstract
Aims: This study aimed to evaluate the hemogram parameters of patients with atopic dermatitis (AD) and contribute to the existing literature.
Methods: This cross-sectional study retrospectively analyzed data from pediatric patients diagnosed with AD, who presented to the Pediatric Allergy and Immunology outpatient clinic at Ümraniye Training and Research Hospital between January 1, 2024, and August 15, 2024. The sociodemographic characteristics, hemogram parameters, total IgE values, allergy history, and allergy test results of the patients were evaluated. Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), systemic immune-inflammation index (SII), systemic inflammatory response index (SIRI), neutrophil/lymphocyte/platelet ratio (NLPR), and pan-immune-inflammation value (PIV) were calculated. Allergen-specific IgE measurements were performed using the ImmunoCAP method, and skin prick tests were conducted for food and inhalant allergens. The severity of AD was classified as mild or moderate-to-severe based on the potency of the topical corticosteroids used by the patients. Statistical analyses were performed using SPSS version 29.0.
Results: A total of 346 patients diagnosed with AD were included in the study. Among the patients, 53.8% were male, and the median age was 32.5 months. Mild AD was identified in 46.5% of the patients, while 53.5% had moderate-to-severe AD. Although sensitization to house dust mites, cats, eggs, and nuts was more frequent in patients with moderate-to-severe AD, no statistically significant difference was found between allergen sensitization and AD severity. Eosinophil count and eosinophillymphocyte ratio (ELR) were significantly higher in moderate-to-severe AD patients compared to those with mild AD (p=0.008 and p=0.004, respectively). No significant difference was found for other hemogram parameters and inflammatory markers. Patients with allergen sensitization had significantly higher WBC, basophil, eosinophil counts, and total IgE levels (p<0.05).
Conclusion: This study evaluated the relationship between hematological parameters and allergen sensitization in AD patients. Eosinophil count and ELR were significantly elevated with increasing AD severity. However, NLR, SII, SIRI, NLPR, and PIV were not associated with AD severity. Patients with allergen sensitization had significantly higher WBC, eosinophil, basophil counts, and total IgE levels. Our findings suggest that eosinophil count and total IgE levels may serve as predictive markers for AD severity and allergen sensitization. Routine measurement of these parameters could offer a practical approach in determining AD severity and allergen sensitization. Further research is needed to clarify the clinical significance of other hematological parameters.

Keywords : IgE, eosinophil, inflammation

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1. Weidinger S, Novak N. Atopic dermatitis.Lancet. 2016;387(10023):1109-1122. doi:10.1016/S0140-6736(15)00149-X
2. Mozryska O. House dust mite sensitivity in atopic children with dectin-1 rs7309123 polymorphism. Alergologia Polska-Polish J Allergol. 2022; 9(3);191-195. doi:10.5114/pja.2022.119232
3. Silverberg JI, Barbarot S, Gadkari A, et al. Atopic dermatitis in the pediatric population: a cross-sectional, international epidemiologic study.Ann Allergy Asthma Immunol. 2021;126(4):417-428.e2. doi:10. 1016/j.anai.2020.12.020
4. Barbarot S, Auziere S, Gadkari A, et al. Epidemiology of atopic dermatitis in adults: results from an international survey.Allergy. 2018;73(6):1284-1293. doi:10.1111/all.13401
5. Yew YW, Thyssen JP, Silverberg JI. A systematic review and meta-analysis of the regional and age-related differences in atopic dermatitis clinical characteristics.J Am Acad Dermatol. 2019;80(2):390-401. doi:10. 1016/j.jaad.2018.09.035
6. Schneider L, Tilles S, Lio P, et al. Atopic dermatitis: a practice parameter update 2012. J Allergy Clin Immunol. 2013;131(2):295-9.e1-27. doi:10. 1016/j.jaci.2012.12.672
7. Di Bari F. Atopic dermatitis and alpha-chemokines. Clin Ter. 2015;166(3): e182-187. doi:10.7417/CT.2015.1852
8. Silverberg JI. Comorbidities and the impact of atopic dermatitis.Ann Allergy Asthma Immunol. 2019;123(2):144-151. doi:10.1016/j.anai.2019. 04.020
9. Bieber T. Atopic dermatitis: an expanding therapeutic pipeline for a complex disease. Nat Rev Drug Discov. 2022;21(1):21-40. doi:10.1038/s41573-021-00266-6
10. Kim BE, Leung DY. Significance of skin barrier dysfunction in atopic dermatitis. Allergy Asthma Immunol Res. 2018;10(3):207-215. doi:10. 4168/aair.2018.10.3.207
11. Furue M, Ulzii D, Vu YH, Tsuji G, Kido-Nakahara M, Nakahara T. Pathogenesis of atopic dermatitis: current paradigm. Iran J Immunol. 2019;16(2):97-107. doi:10.22034/IJI.2019.80253
12. Kolb L, Ferrer-Bruker SJ. Atopic dermatitis. [Updated 2022 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls. Publishing; 2022. Available from: https://www.ncbi.nlm.nih. gov/books/NBK448071/
13. Kezic S, O&rsquo;Regan GM, Lutter R, et al. Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency. J Allergy Clin Immunol. 2012;129(4):1031-1039.e1. doi:10.1016/j.jaci.2011.12.989
14. Ozdin M. The relationship between hematological and allergic parameters in children with atopic dermatitis. Balıkesir Med J. 2020;4(3): 1-6. doi:10.33716/bmedj.760653
15. Simon D, Braathen LR, Simon HU. Eosinophils and atopic dermatitis. Allergy. 2004;59(6):561-570. doi:10.1111/j.1398-9995.2004.00476.x
16. Hamad DA, Aly MM, Abdelhameid MA, et al. Combined blood indexes of systemic inflammation as a mirror to admission to intensive care unit in COVID-19 patients: a multicentric study. J Epidemiol Glob Health. 2022;12(1):64-73. doi:10.1007/s44197-021-00021-5
17. Moldovan F, Gligor A, Moldovan L, Bataga T. The impact of the COVID-19 pandemic on the orthopedic residents: a pan-romanian survey.Int J Environ Res Public Health. 2022;19(15):9176. doi:10.3390/ijerph19159176
18. Xia Y, Xia C, Wu L, Li Z, Li H, Zhang J. Systemic immune inflammation index (SII), system inflammation response index (SIRI) and risk of all-cause mortality and cardiovascular mortality: a 20-year follow-up cohort study of 42,875 US adults.J Clin Med. 2023;12(3):1128. doi:10. 3390/jcm12031128
19. Hollis K, Proctor C, McBride D, et al. Comparison of urticaria activity score over 7days (UAS7) values obtained from once-daily and twice-daily versions: results from the ASSURE-CSU study.Am J Clin Dermatol. 2018;19(2):267-274. doi:10.1007/s40257-017-0331-8
20. Guven DC, Sahin TK, Erul E, Kilickap S, Gambichler T, Aksoy S. The association between the pan-immune-inflammation value and cancer prognosis: a systematic review and meta-analysis.Cancers (Basel). 2022; 14(11):2675. doi:10.3390/cancers14112675
21. Sari S, Soysal DG, Turkeli A. Atopik dermatit tanılı &ccedil;ocukların aile bireylerinde yaşam ve uyku kalitesinin değerlendirilmesi.Pam Tıp Derg. 2022;15(3):475-483. doi:10.31362/patd.1031195
22. &Ccedil;&ouml;mlek F&Ouml;, Toprak A, Nursoy MA. &Ccedil;ocukluk &ccedil;ağı atopik dermatitli hastalarda ve ailelerinde dermatolojik yaşam kalitesi değerlendirilmesi.T&uuml;rk Pediatri Arş,2020;55(3):270-276.
23. Ciğerci G&uuml;naydın N, G&uuml;ler Ş, Yerlioğlu &Ouml;, &Ouml;zt&uuml;rk M, Dınlamaz B, Samancı N. Atopik dermatitli hastalarda besin alerjisi sıklığının ve hastalık şiddetinin değerlendirilmesi. Pam Tıp Derg. 2021;14(4):878-885. doi:10.31362/patd.861596
24. Inokuchi-Sakata S, Ishiuji Y, Katsuta M, et al. Role of eosinophil relative count and neutrophil-to-lymphocyte ratio in the assessment of severity of atopic dermatitis.Acta Derm Venereol. 2021;101(7):adv00491. doi:10. 2340/00015555-3838
25. Dogru M, Citli R. The neutrophil-lymphocyte ratio in children with atopic dermatitis: a case-control study.Clin Ter. 2017;168(4):e262-e265. doi:10.7417/T.2017.2017
26. Bhat T, Teli S, Rijal J, Bhat H, Raza M, Khoueiry G. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther. 2013;11(1):55-59. doi:10.1586/erc.12.159
27. S&ouml;ğ&uuml;tl&uuml; Y, Altaş U. Predictive value of neutrophil-lymphocyte ratio and other inflammation indices in febrile seizures in children.J Clin Med. 2024;13(17):5330. doi:10.3390/jcm13175330
28. Altas U, Unlu DA, Gulluce H, et al. Evaluation of the relationship between laboratory parameters and allergy tests in children with atopic dermatitis.Chron Precis Med Res. 2023;4(2):168-171. doi:10.5281/zenodo.8201981
Article available in :
Volume 3, Issue 2, 2025
Page : 27-31
https://doi.org/10.51271/JCOGP-0044
Article Information
Received : 19 Eki 2024
Accepted : 07 Oca 2025
Published : 11 Nis 2025
Corresponding Author :

Halil Alkaya: Department of Pediatric Allergy and Immunology, Ümraniye Training and Research Hospital, University of Health Sciences, İstanbul, Turkey

[email protected]
Citation : Alkaya H, Altaş U, Çevik S, Altaş ZM, Özkars MY. Evaluation of hemogram parameters in patients with atopic dermatitis. J Controv Obstetr Gynecol Ped. 2025;3(2):27-31.

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