JCOGP

As of January 2023, our "Journal of Controversies Obstetrics & Gynecology and Pediatrics" has been published under the Medihealth Academy to publish all articles, reviews and case reports on Pediatrics, especially in the field of Obstetrics and Gynecology. In order to facilitate the citation of the articles, to take our place in internationally respected indexes and to reach a wider readership, we will pay attention to the fact that our article language is only English in terms of acceptance.

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Original Article
The impact of vitamin D supplementation on reproductive outcomes in women with polycystic ovary syndrome: a randomized controlled trial
Aims: This study aims to evaluate the effectiveness of vitamin D supplementation treatment on reproductive outcomes in women with polycystic ovary syndrome (PCOS).
Methods: The study involved 235 women aged 20-40 with PCOS who were seeking treatment at Private infertility Clinic in Turkiye. The participants were divided into two groups: 123 in the control group and 115 in the intervention group, chosen at random. Their age, body-mass index (BMI), education level, employment status, and PCOS symptoms were assessed. Statistical significance between the case and control groups was compared using the chi-squared and Fisher’s exact tests.
Results: There were no significant differences in age, BMI, education level, employment status, and PCOS symptoms such as menstrual irregularity, amenorrhea, hirsutism, hair loss and acne between the intervention and control groups (p-value>0.05). There were significant differences in clinical pregnancy rates (CPR) between the intervention and control groups (p-value<0.05). The two groups showed no significant differences in live birth rates and clinical miscarriage rates (p-value>0.05).
Conclusion: Based on the findings, it has been revealed that supplementing with vitamin D has a positive impact on CPR. Vitamin D supplementation may support the improvement of fertility in women with PCOS, although the exact mechanisms and effectiveness are still under study.


1. G&uuml;rb&uuml;z T, G&ouml;kmen O, G&uuml;ng&ouml;r ND. Polikistik over sendromu bulunan kadınlarda glikoz potasyum oranının tanısal değerinin ins&uuml;lin ile karşılaştırılması. Cukurova Med J. 2021;46(1):381-386. doi:10.17826/cumj.782931
2. Salari N, Nankali A, Ghanbari A, et al. Global prevalence of polycystic ovary syndrome in women worldwide: a comprehensive systematic review and meta-analysis.Arch Gynecol Obstet. 2024;310(3):1303-1314. doi:10.1007/s00404-024-07607-x
3. G&uuml;rb&uuml;z T, G&uuml;ng&ouml;r ND, Yurci A. Does intracytoplasmic sperm injection increase the risk of gestational diabetes in patients with polycystic over? Anatol Curr Med J. 2021;3(1):53-58. doi:10.38053/acmj.837292
4. G&uuml;rkan N, G&uuml;ng&ouml;r ND, Madenli AA, Tosun ŞA. Evaluation of the impact of platelet-rich plasma in women with reduced ovarian reserve. J Health Sci Med. 2022;5(5):1334-1338. doi:10.32322/jhsm.1117530
5. Siddiqui S, Mateen S, Ahmad R, Moin S. A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS).J Assist Reprod Genet. 2022;39(11):2439-2473. doi:10.1007/s10815-022-02625-7
6. G&uuml;rb&uuml;z T, G&ouml;kmen O, Madenli AA, Dilbaz B. R-Spondin1 and tumor necrosis factor-alpha in infertile women with polycystic ovary syndrome: relationships with insulin resistance and other parameters. J Health Sci Med. 2023;6(2):449-455. doi:10.32322/jhsm.1210721
7. Costello MF, Misso ML, Balen A, et al. A brief update on the evidence supporting the treatment of infertility in polycystic ovary syndrome.Aust N Z J Obstet Gynaecol. 2019;59(6):867-873. doi:10.1111/ajo.13051
8. Mohan A, Haider R, Fakhor H, et al. Vitamin D and polycystic ovary syndrome (PCOS): a review.Ann Med Surg (Lond). 2023;85(7):3506-3511. doi:10.1097/MS9.0000000000000879
9. Siddiqee MH, Bhattacharjee B, Siddiqi UR, Meshbahur Rahman M. High prevalence of vitamin D deficiency among the South Asian adults: a systematic review and meta-analysis.BMC Public Health. 2021;21(1): 1823. doi:10.1186/s12889-021-11888-1
10. Ghorbani Z, Togha M, Rafiee P, et al. Vitamin D in migraine headache: a comprehensive review on literature.Neurol Sci. 2019;40(12):2459-2477. doi:10.1007/s10072-019-04021-z
11. Mu Y, Cheng D, Yin TL, Yang J. Vitamin D and polycystic ovary syndrome: a narrative review.Reprod Sci. 2021;28(8):2110-2117. doi:10. 1007/s43032-020-00369-2
12. Ali AT. Polycystic ovary syndrome and metabolic syndrome. Ceska Gynekol. 2015;80(4):279-289.
13. Menichini D, Facchinetti F. Effects of vitamin D supplementation in women with polycystic ovary syndrome: a review.Gynecol Endocrinol. 2020;36(1):1-5. doi:10.1080/09513590.2019.1625881
14. Zhao X, An X, Yang C, Sun W, Ji H, Lian F. The crucial role and mechanism of insulin resistance in metabolic disease.Front Endocrinol (Lausanne). 2023;14:1149239. doi:10.3389/fendo.2023.1149239
15. Yang M, Shen X, Lu D, et al. Effects of vitamin D supplementation on ovulation and pregnancy in women with polycystic ovary syndrome: a systematic review and meta-analysis.Front Endocrinol (Lausanne). 2023;14:1148556. doi:10.3389/fendo.2023.1148556
16. Yahya AA, Abdulridha MK, Al-Rubuyae BJ, Al-Atar HA. The effect of vitamin D and co-enzyme Q10 replacement therapy on hormonal profile and ovulation status in women with clomiphene citrate resistant polycystic ovary syndrome. J Pharm Sci Res. 2019;11(1):208-215.
17. Rasheedy R, Sammour H, Elkholy A, Salim Y. The efficacy of vitamin D combined with clomiphene citrate in ovulation induction in overweight women with polycystic ovary syndrome: a double blind, randomized clinical trial.Endocrine. 2020;69(2):393-401. doi:10.1007/s12020-020-02315-3
18. Aflatoonian A, Arabjahvani F, Eftekhar M, Sayadi M. Effect of vitamin D insufficiency treatment on fertility outcomes in frozen-thawed embryo transfer cycles: a randomized clinical trial.Iran J Reprod Med. 2014;12(9):595-600.
19. Hasan HA, Barber TM, Cheaib S, Coussa A. Preconception vitamin D level and invitro fertilization: pregnancy outcome.Endocr Pract. 2023; 29(4):235-239. doi:10.1016/j.eprac.2023.01.005
20. Rashidi B, Haghollahi F, Shariat M, Zayerii F. The effects of calcium-vitamin D and metformin on polycystic ovary syndrome: a pilot study.Taiwan J Obstet Gynecol. 2009;48(2):142-147. doi:10.1016/S1028-4559(09)60275-8
21. Pal L, Zhang H, Williams J, et al. Vitamin D status relates to reproductive outcome in women with polycystic ovary syndrome: secondary analysis of a multicenter randomized controlled trial.J Clin Endocrinol Metab. 2016;101(8):3027-3035. doi:10.1210/jc.2015-4352
22. V&aacute;rb&iacute;r&oacute; S, Tak&aacute;cs I, Tuu L, et al. Effects of vitamin D on fertility, pregnancy and polycystic ovary syndrome-a review.Nutrients. 2022; 14(8):1649. doi:10.3390/nu14081649
23. Nosseir M, Sadek A, Awad S, Edris T. Effect of vitamin D supplementation in improving pregnancy rates in infertile women with PCOS. Benha J Appl Sci. 2021;6(2):267-272. doi:10.21608/bjas.2021.169462
24. Zhuang L, Cui W, Cong J, Zhang Y. Efficacy of vitamin D combined with metformin and clomiphene in the treatment of patients with polycystic ovary syndrome combined with infertility.Iran J Public Health. 2019; 48(10):1802-1809.
25. Sobhy Menshawy Khalifa S, Gaber Eldamaty W, Tharwat Abo Dakika A, Zaeim Hafez Ahmed M, Abdelbaeth Hassan Elfiky M, Adel Hegazy G. Clinical pregnancy and miscarriage rates in relation to vitamin D supplementation among women with hyper androgenic PCOS: a prospective study.Int J Fertil Steril. 2025;19(1):17-23. doi:10.22074/ijfs. 2024.2001145.1462
26. Katyal G, Kaur G, Ashraf H, et al. Systematic review of the roles of inositol and vitamin D in improving fertility among patients with polycystic ovary syndrome.Clin Exp Reprod Med. 2024;51(3):181-191. doi:10.5653/cerm.2023.06485
27. Piao C, Li J, Liang C, et al. Effect of vitamin D on pregnancy in women with polycystic ovary syndrome: retrospective and prospective studies.Reprod Biomed Online. 2024;49(2):103909. doi:10.1016/j.rbmo. 2024.103909
28. Sulaiman EA, Dhiaa S, Merkhan MM. Overview of vitamin D role in polycystic ovarian syndrome. MMSL. 2022;91(1):37-43. doi:10.31482/mmsl.2021.027
29. Firouzabadi Rd, Aflatoonian A, Modarresi S, Sekhavat L, MohammadTaheri S. Therapeutic effects of calcium &amp; vitamin D supplementation in women with PCOS.Complement Ther Clin Pract. 2012;18(2):85-88. doi:10.1016/j.ctcp.2012.01.005
30. Shojaeian Z, Sadeghi R, Latifnejad Roudsari R. Calcium and vitamin D supplementation effects on metabolic factors, menstrual cycles and follicular responses in women with polycystic ocvary syndrome: a systematic review and meta-analysis.Caspian J Intern Med. 2019;10(4): 359-369. doi:10.22088/cjim.10.4.359
Volume 3, Issue 2, 2025
Page : 37-41
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