JCOGP
Journal of Controversies in Obstetrics & Gynecology and Pediatrics

As of January 2023, our "Journal of Controversies Obstetrics & Gynecology and Pediatrics" has been published under the Medihealth Academy to publish all articles, reviews and case reports on Pediatrics, especially in the field of Obstetrics and Gynecology. In order to facilitate the citation of the articles, to take our place in internationally respected indexes and to reach a wider readership, we will pay attention to the fact that our article language is only English in terms of acceptance.

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Original Article
Comparative study of metabolic syndrome and cardiovascular risk in women with and without polycystic ovary syndrome
Abstract
Aims: Polycystic ovary syndrome (PCOS) is ssociated with an increased risk of metabolic syndrome (MetS) and cardiovascular diseases (CVD). This study aimed to evaluate the prevalence of MetS and cardiovascular risk factors in women with and without PCOS to better understand the broader implications of the syndrome.
Methods: A total of 400 women participated: 200 with PCOS (Rotterdam criteria) and 200 age-matched controls. Data collected included body mass index (BMI), fasting glucose, lipid profiles, blood pressure, and inflammatory markers (CRP and IL-6). MetS was defined using NCEP ATP III criteria. Statistical analyses were performed to compare metabolic and cardiovascular markers between groups, with a significance level set at p < 0.05.
Results: MetS prevalence was significantly higher in the PCOS group (60%) compared to controls (30%) (p < 0.01). Insulin resistance was greater in the PCOS group, with a mean HOMA-IR of 3.2 versus 1.8 in controls (p < 0.001), and fasting glucose levels were elevated (110 mg/dL vs. 95 mg/dL, p < 0.001). Lipid profiles were more atherogenic in PCOS, with higher triglycerides (150 mg/dL vs. 100 mg/dL, p < 0.01), higher LDL cholesterol (130 mg/dL vs. 110 mg/dL, p < 0.01), and lower HDL cholesterol (40 mg/dL vs. 50 mg/dL, p < 0.05). Blood pressure was also elevated in PCOS (systolic: 135 mm Hg vs. 120 mm Hg, p < 0.05; diastolic: 85 mm Hg vs. 75 mm Hg, p < 0.05). Inflammatory markers were significantly higher in PCOS, including CRP (4.2 mg/L vs. 2.1 mg/L) and IL-6 (6.0 pg/mL vs. 3.0 pg/mL) (both p < 0.01).
Conclusion: Metabolic and cardiovascular risk factors are significantly more prevalent in women with PCOS. Early intervention, including management of insulin resistance, dyslipidemia, hypertension, and inflammation, is crucial to reducing cardiovascular morbidity and long-term health risks in this population.

Keywords : Polycystic ovary syndrome, metabolic syndrome, cardiovascular risk, insulin resistance, dyslipidemia

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Article available in :
Volume 3, Issue 3, 2025
Page : 56-61
https://doi.org/10.51271/JCOGP-0050
Article Information
Received : 03 Şub 2025
Accepted : 20 Şub 2025
Published : 07 Tem 2025
Corresponding Author :

Nurgül Ulusoy: Private Gynecology and Obstetric Clinic, İstanbul, Turkiye

[email protected]
Citation : Ulusoy N, Ağar M, Çalı Öztürk H. Comparative study of metabolic syndrome and cardiovascular risk in women with and without polycystic ovary syndrome. J Controv Obstetr Gynecol Ped. 2025;3(3):56-61.

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