JCOGP
Journal of Controversies in Obstetrics & Gynecology and Pediatrics

As of January 2023, our "Journal of Controversies Obstetrics & Gynecology and Pediatrics" has been published under the Medihealth Academy to publish all articles, reviews and case reports on Pediatrics, especially in the field of Obstetrics and Gynecology. In order to facilitate the citation of the articles, to take our place in internationally respected indexes and to reach a wider readership, we will pay attention to the fact that our article language is only English in terms of acceptance.

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Case Report
Complement-mediated warm autoimmune hemolytic anemia associated with acute poststreptococcal glomerulonephritis: a pediatric case report
Abstract
Acute poststreptococcal glomerulonephritis (APSGN) is one of the most common causes of acute nephritic syndrome in childhood; however, hematological complications are rarely associated with this disease. This article presents a case of a 6.5-year-old male who presented with complaints of pallor and fatigue after a recent upper respiratory tract infection and was diagnosed with autoimmune hemolytic anemia. During hospitalization, the patient developed hypertension, oliguria, and gross hematuria; further evaluation revealed elevated antistreptolysin O levels and markedly low serum complement component 3 levels, leading to a diagnosis of APSGN. The direct antiglobulin test revealed immunoglobulin G negativity along with complement positivity, findings consistent with complement-mediated warm-type autoimmune hemolytic anemia. The patient received corticosteroid therapy, supportive treatment, and antihypertensive agents; following treatment, rapid improvement in hemoglobin levels and complete resolution of renal and hematological findings were achieved. This case highlights the rare association of APSGN with complement-mediated autoimmune hemolytic anemia, emphasizing the need to consider immune-mediated hematological complications in children with unexplained anemia associated with nephritic syndrome.

Keywords : Acute poststreptococcal glomerulonephritis, autoimmune hemolytic anemia, complement-mediated hemolysis, direct antiglobulin test

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Article available in :
Volume 4, Issue 1, 2026
Page : 22-24
https://doi.org/10.51271/JCOGP-0068
Article Information
Received : 31 Oca 2026
Accepted : 31 Oca 2026
Published : 31 Oca 2026
Corresponding Author :

Serkan Tursun: Department of Pediatrics, Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkiye

[email protected]
Citation : Tursun S, Toprak Ş, Tandırcıoğlu ÜA, Albayrak M. Complement-mediated warm autoimmune hemolytic anemia associated with acute poststreptococcal glomerulonephritis: a pediatric case report. J Controv Obstetr Gynecol Ped. 2026;4(1):22-24.

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