JCOGP
Journal of Controversies in Obstetrics & Gynecology and Pediatrics

As of January 2023, our "Journal of Controversies Obstetrics & Gynecology and Pediatrics" has been published under the Medihealth Academy to publish all articles, reviews and case reports on Pediatrics, especially in the field of Obstetrics and Gynecology. In order to facilitate the citation of the articles, to take our place in internationally respected indexes and to reach a wider readership, we will pay attention to the fact that our article language is only English in terms of acceptance.

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Letter to the Editor
Comments on the "Impact of dienogest therapy on CA125 levels, hormonal profile, and systemic inflammatory indices in endometriosis"
Abstract
Endometriosis is increasingly recognized as a systemic inflammatory condition, and dienogest is widely used as a medical treatment option. In their recent article, Bulut Arıkan and Sağsöz reported that dienogest therapy in women with endometriosis was associated with reductions in CA125, platelet-to-lymphocyte ratio (PLR), leukocyte count, and plateletcrit, alongside small increases in hemoglobin, hematocrit, and red blood cell indices. Based on these findings, the authors suggested that dienogest may exert anti-inflammatory effects and preserve endocrine homeostasis. In this letter, we highlight several methodological and interpretative issues that warrant caution. The retrospective, single-center, uncontrolled pre–post design and generally small effect sizes limit the extent to which causality and clinical significance can be inferred. Moreover, key systemic inflammatory indices such as neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, and systemic inflammation response index did not change significantly, which argues against a broad systemic anti-inflammatory effect. Finally, the proposed mechanisms for hematological improvement and endocrine safety remain speculative in the absence of detailed clinical outcomes.

Keywords : CA125, inflammation, endometriosis

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1. Bulut Arıkan F, Sağsöz N. Impact of dienogest therapy on CA125 levels, hormonal profile, and systemic inflammatory indices in endometriosis. J Controv Obstetr Gynecol Ped. 2026;4(2):25-30. doi:10.51271/JCOGP-0069
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3. Araştırma Türleri. Hacettepe Üniversitesi Biyoistatistik Anabilim Dalı. “Araştırma Türleri” eğitim notu (PDF). Erişim tarihi: 14 May 2026.
4. Kurt DS, Akay A, Ulusoy CO, Kurt A, Karabay G, Keskin HL. Evaluation of serum-based inflammatory and haematological markers in patients with endometriosis: a case-control study. Eur J Obstet Gynecol Reprod Biol. 2025;315:114751. <a href="https://doi.org/10.1016/j.ejogrb.2025.114751">doi:10.1016/j.ejogrb.2025.114751</a>
5. Gete DG, Doust J, Mortlock S, Montgomery G, Mishra GD. Risk of iron deficiency in women with endometriosis: a population-based prospective cohort study. Womens Health Issues. 2024;34(3):317-324. <a href="https://doi.org/10.1016/j.whi.2024.03.004">doi:10.1016/j.whi.2024.03.004</a>
Article available in :
Volume 4, Issue 3, 2026
Page : 79-82
https://doi.org/10.51271/JCOGP-0078
Article Information
Received : 18 May 2026
Accepted : 22 Haz 2026
Published : 30 Tem 2026
Corresponding Author :

Erkan Mavigök: Department of Obstetrics and Gynecology, Private Megapoint Hospital, Kahramanmaraş, Turkiye

[email protected]
Citation : Mavigök E. Comments on the interpretation of the effects of dienogest therapy on CA125 and systemic inflammatory indices in endometriosis. J Controv Obstetr Gynecol Ped. 2026;4(3):79-82. doi:10.51271/JCOGP-0078

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